Preoperative, postoperative, or obstetric sedation. https://medlibrary.org/lib/rx/meds/promethegan-5/. Dinoprostone There are no adequate and well-controlled studies of Promethazine HCl Suppositories in pregnant women. Minor transfusion and/or amelioration of allergic reactions may be controlled with 12.5 mg doses. A linear relationship between peak height ratio (promethazine-promazine) and promethazine concentration is found up to a concentration of 600 micrograms/ml. Promethazine HCl is a racemic compound; the empirical formula is C17H20N2SHCl and its molecular weight is Stay informed and get access to the latest news, 4500 East-West Highway, Keep from freezing. Parenteral formulations: Store ampoules in the carton until ready to use. Drug classes: Antihistamines, Phenothiazine antiemetics. Store promethazine rectal suppositories in a refrigerator between 36 - 46F. Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions. Promethazine should not routinely be used to treat vomiting in children; it should only be used in specific cases when a doctor decides that it is needed. WARNING: Duplication for commercial use must be authorized by ASHP. This may lead to a higher chance of getting an. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. The effect on later growth and development of the newborn is unknown. <> For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary. WebA stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. These results suggest that in conscious rats many factors such as a locomotor hyperactivity and enhancement of gastrointestinal motility caused by the rectal administration mask the real character of suppositories. Room-temperature storage of medications labeled for The average parenteral dose given during established labor is 50 mg. 12.5 mg, white, bullet-shaped suppository wrapped in silver foil. Bookshelf Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you have any of these health problems: If you have any of these health problems: Low blood cell count or poor bone marrow function. Promethazine is well absorbed from the gastrointestinal tract. Parenteral: 25 mg IM or IV once, and may be repeated within 2 hours if necessary Indomethacin sustained-release suppositories containing sugar ester. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. Phenergan - Food and Drug Administration It may cause very bad and sometimes deadly breathing problems. Doses should be adjusted to the age and severity of the patient. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects. CNS Depressants Promethazine HCl Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. An official website of the United States government. official website and that any information you provide is encrypted Subcutaneous administration is contraindicated. Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities. Atropine-like signs and symptoms-dry mouth, fixed, dilated pupils, flushing, as well as gastrointestinal symptoms-may occur. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=5f079815-f48b-8b21-2130-7f791d967c9a, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. It is used to ease pain . Development and validation of a HPLC method for the analysis of promethazine hydrochloride in hot-melt extruded dosage forms. Patients should be advised to report any involuntary muscle movements. PRECAUTIONS- Information for Patients and Drug Interactions). Stability of Refrigerated and Frozen Drugs - Care Plus Pharmacy Comments: 2 years and older: sharing sensitive information, make sure youre on a federal Alcohol can make the side effects of promethazine worse. Stimulation may be evident, especially in children and geriatric patients. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Nakajima T, Takashima Y, Furuya A, Ozawa Y, Kawashima Y. Chem Pharm Bull (Tokyo). The following laboratory tests may be affected in patients who are receiving therapy with promethazine HCl: Keep containers out of reach of children and pets. Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in children who are 2 years of age older and 1 inch (2.5 centimeters) in adults. Carcinogenicity Under the conditions of the National Toxicology Program (NTP) studies, there was no evidence of If you are allergic to this medicine (promethazine suppositories); any part of this medicine (promethazine suppositories); or any other drugs, foods, or substances. suppository. This drug should be administered at a rate no greater than 25 mg/min. 0713-0526-12, The American Society of Health-System Pharmacists AHFS Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. continuous twisting movements of the hands and feet, wide pupils (black circles in the middle of the eyes), difficulty falling asleep or staying asleep, hallucinations (seeing things or hearing voices that do not exist), overwhelming or unmanageable fear or emotion, uncontrollable shaking of a part of the body, sore throat, fever, chills, and other signs of infection, inability to respond to people around you, swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs. Usual adult dosage is 50 mg promethazine HCl with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. 03/2020 VC7409, Boxed Warnings, PMC Motion Sickness WARNINGSCNS Depression and DOSAGE AND ADMINISTRATION Please enable it to take advantage of the complete set of features! Be sure to mention any of the following: antidepressants ('mood elevators') such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; azathioprine (Imuran);barbiturates such as phenobarbital (Luminal); cancer chemotherapy; epinephrine (Epipen); ipratropium (Atrovent)medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar); narcotics and other pain medication; sedatives; sleeping pills;and tranquilizers. Federal government websites often end in .gov or .mil. Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Epinephrine Because of the potential for promethazine HCl to reverse epinephrines vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Promethazine HCl Suppositories overdose. WebPromethazine Suppositories Insulin Formulations Latanoprost Ophthalmic Drops Etonogestrel/Ethinyl Estradiol Vaginal Rings Name common medications stored at room temperature Antibiotic powders for reconstitution How is mannitol stored? WebTo insert a promethazine suppository, follow these steps: If the suppository feels soft, hold it under cold, running water for 1 minute. Ask your doctor or pharmacist if you are not sure. All Rights Reserved. The effect of drug concentration on the thermal (dark) degradation of promethazin hydrochloride in aqueous solution. If you are taking any drugs that can stop your bone marrow from making some of the cells that your body needs. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). Preoperative medication: 1.1 mg/kg IM, IV, orally, or rectally once. The .gov means its official. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. MeSH Indomethacin (Rectal Route) Proper Use - Mayo Clinic This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. sharing sensitive information, make sure youre on a federal photolytic degradation studies of promethazine Promethazine Hydrochloride Suppositories USP, 12.5 mg and 25 WARNINGSRespiratory Depression). Talk with the doctor. Prophylactic doses may be used to prevent nausea and vomiting during surgery and the postoperative period. Events, If it is close to the time for your next dose, skip the missed dose and go back to your normal time. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drowsiness is the most prominent CNS effect of this drug. Use. Adverse reactions include burning, pain, thrombophlebitis, tissue necrosis, and gangrene. can do this. WebPromethazine HCl Suppositories are for rectal administration only. 65 years and older: Elderly patients should be given lower initial doses and should be closely monitored for adverse events. Do not freeze. Select one or more newsletters to continue. WebA stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. When promethazine is used to treat motion sickness, it is taken 30 to 60 Accessibility This drug should not be used to treat nausea and vomiting of unknown etiology. The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. This possibility should be considered with Promethazine HCl Suppositories. Once treatment begins, the dose should be reduced to the smallest effective amount needed to control symptoms. PROMETHAZINE HYDROCHLORIDE SUPPOSITORIES, USP Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 H-Phenothiazine, 10-ethanamine, advice about side effects. Promethazine HCl Suppositories may lower seizure threshold. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Oxygen may also be administered. Perennial and seasonal allergic rhinitis. Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are seen. Brand name: Phenergan 2 SHCl and its molecular weight is 320.88. WebWhen promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. Clipboard, Search History, and several other advanced features are temporarily unavailable. Usual Pediatric Dose for Nausea/Vomiting. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. FROZEN Drugs If you are taking promethazine liquid, do not use a household spoon to measure your dose. Lie down on your left side and raise your right knee to your chest. Talk to your doctor about the risks of giving promethazine to your child. Promethazine HCl Rectal Suppositories, USPare available in boxes of 12 and 1000 as follows: WebPromethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Dermographism. Amelioration of allergic reactions to blood or plasma. Caution should be exercised when administering parenteral formulations in pediatric patients 2 years of age and older; it is recommended that the lowest effective dose of oral formulations be used in and concomitant administration of other drugs with respiratory depressant effects be avoided in this patient population. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. Promethazine HCl Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug. Phenergan (Promethazine HCl) Suppositories are for rectal administration only. Amelioration of allergic reactions to blood or plasma. Promethazine HCl Suppositories,USPare for rectal administration only. what signs you had. Rectally administered indomethacin should be used with caution in patients with hemorrhoids, anal, or rectal inflammation. WebPROMETHAZINE (proe METH a zeen) prevents and treats the symptoms of an allergic reaction. Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 <> Stay Cool: Storing Meds in the Fridge or Freezer
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